Everything you need to know about Estradiol / Progynova

Description of the drug

Estradiol is the main active pharmaceutical ingredient present in Progynova 1 mgtablet. Estradiol is an estrogen a female hormone that is produced by the ovaries. It is used as a harmone replacement therapy by a women that help in reducing the symptoms of menopause such as hot flashes and vaginal dryness, these symptoms occurs due to the less estrogen produced by the body. This medication is used to resist these symptoms and to prevent loss of bones. This drug comes in an oral form, a transdermal skin patch, a vaginal ring or as a topical gel, spray, or emulsion.

Indications and Usage of Estradiol

Progynova 1 mg is mostly used as a hormone replacement in menopausal women. This drug is indicated to used by a woman in order to treat hot flushes, who are experiencing menopause. This medicine is also used to prevent osteoporosis, replace estrogen in women with ovarian failure, or as part of a cancer treatment regimen. Estradiol is in a class of drugs called estrogen hormones. It works by replacing the estrogen that the body normally produces.

Dosage and Administration for Estradiol

-Recommended Estradiol dose:

The dose may vary according to the patient condition therefore it is advised to take this medicament as per your doctor’s direction.

-Method of Administration:

Progynova is available in the form of a tablet taken orally by mouth, usually once a day with a glass of water as directed by your doctor. Do not break, crush, or chew the tablet, it will cause you a bitter taste.

-Missed dose

If you miss one or more doses; take the next dose on time.If not taken on time it will increase the risk of becoming pregnant. It is advised to talk to your doctor and do not take more than your doctor is prescribed.

– Estradiol Overdose:

The overdose of any drug can cause severe effects. The overdose symptoms may include extreme drowsiness, agitation, aggression, shallow breathing, weakness, fainting, headache, vomiting and many other allergic symptoms. In the case of an overdose, you should immediately contact your doctor.

Forms and Strengths of Estradiol

The drug Estradiolis available on our website in the following strength and forms under the brand name of:

Progynova 1 mg Tablets
Progynova 2 mg Tablets
Climara 3.8 mg Patches
Climara Forte 7.6 mg Patches
Oestrogel 1.5 mg (2.5 gm) Gel Tube
E2 – 0.025 mg Vaginal Tablets
Vegifem 25 mg Vaginal Tablets

Contraindications for taking Estradiol.

This drug should not be used in patients with known or suspected hypersensitivity to any of the ingredients present in the formulation.
This drug should not be used in pregnant women. It may harm the unborn baby
This drug should not be used in lactating women, using this medicine while breastfeeding is harmful to the new born baby as this drug may pass through the breast milk.
Do not use this medication if the patient has had a cancer, such as breast cancer or a cancer of the womb lining or ovary.
This drug should not be used in women, who are suffering from unexplained abnormal vaginal bleeding.
Do not use this medication if you are having the habit of smoking and are older than 35 years of age.
This medicine should not be used in those patients, who is having the highest risk of venous or arterial thrombosis diseases.
This drug should not be given to those women who are suffering from uncontrolled high blood pressure, a heart disease, a blood clotting disorder.
This medicament is contraindicated for the male patients.

Warnings and precautions

Remember that Estradiol cannot be consumed by patients who are allergic to the medicine and its ingredients. Before buying Progynova 1 mg tablet online, it is necessary to do a thorough research on its ingredients.
Using estrogen alone may increase the chances of getting cancer of the uterus. If you experienced any vaginal bleeding, which is undiagonosed. Vaginal bleeding after menopause may be a sign of cancer, therefore in this case contact your doctor immediately.
If a patient is suffering from any kind of liver and kidney problem, including dialysis treatment, mental disorder such as depression,this drug is harmful in these conditions, therefore, it is advised to consult your doctor and let him know about your medical history prior taking this drug.
If the patient is suffering from Thrombosis. Thrombosis is the formation of a blood clot in a blood vessel such as deep venous thrombosis or the lungs such as pulmonary embolism. In these conditions this drug should not be consumed without consulting the doctor. It is advised to take this drug only after consulting and prescription of the doctor.
This drug is not suitable, if the patient is suffering from jaundice. Consult your doctor before taking this medicament.
This drug is not suitable for those patients having a heart problem like angina, high blood pressure, or a heart attack. Consult your doctor first, if you have any kind of heart problem before taking this medication.
This drug is not suitable for those patients who are suffering from asthma, diabetes, migraine or an epilepsy problem. In these conditions, consult your doctor before taking this medicament.
This drug is not suitable for those patients, if they ever had bleeding in the brain, stroke, heart attack, or other serious blood vessel problems. In this case, consult your doctor before taking this medicament.
This drug is not suitable for those women who have a history of breast nodules, fibrocystic disease of the breast, an abnormal breast x-ray or mammogram, or irregular or scanty menstrual periods. Consult your doctor before taking this medicament.
If the patient has reported any kind of allergic reaction in the past with any kind of food, dyes, or medicines, then consult your doctor before applying this medicament.
This drug is not suitable, if the patient is having any blood problem.
This drug is not suitable for those patients, having surgery or will be confined to a bed or a chair for a long period of time. Consult your doctor regarding the same prior taking this medicine.
This drug is not suitable for those patients, suffering from tuberculosis. Consult your doctor, let him know about your medical problem before taking this medicament.
This drug is not suitable for those patients, who are overweight, having a high cholesterol level or triglycerides, or having a fluid retention or a swelling problems. Before taking this drug, consult your doctor regarding your medical problem.
This drug is not suitable for those women, who are suffering from any kind of cancer. It is advised to tell your doctor about your disease before taking this medicament.
If the patient has reported any kind of allergic reaction in the past with any kind of food, dyes, or medicines, then consult your doctor before applying this medicament.
Use this drug with caution in elderly patients, older adults may be more sensitive to the side effects of this drug.

Side effects of using Estradiol

Tell your doctor if you have any side effects that bothers you or does not go away.

Some common side effects that can occur:

Changes in menstrual bleeding, eg., irregular bleeding or sometimes stopping of bleeding.
Mood changes, including depression.
Decreased sex drive.
Headache.
Nausea.
Acne.
Breast tenderness.
Weight gain.
Rash or hives.
Ectopic pregnancy

Some rare side effect can occur which will be serious :-

Fever
Shortness of breath
Blurred vision
Jaundice
Mood swings
Vaginal discharge
Weight fgain
Hair loss
Cysts on the ovaries
Painful menstrual cycle
Acne
Less sexual desire
Migraine
Signs of blood clot
Irritation or itching of the skin in or around the vagina.
Breasts become swollen, tender or painful
Burning off your skin

Drug Interactions

These are the drugs that can alter the pharmacological effect of Estradiol-:

Abiraterone acetate
Amiodarone
Anastrozole
Aripiprazole
Ascorbic acid (vitamin C)
Atorvastatin
“Azole” antifungals (e.g., ketoconazole, itraconazole, vorionazole)
Barbiturates (e.g., phenobarbital)
Bosentan
Blood pressure-lowering medications (e.g., propranolol, enalapril, diltiazem)
Carbamazepine
Carvedilol
Celecoxib
Cobicistat
Corticosteroids (e.g., hydrocortisone, prednisolone, prednisone)
Crizotinib
Cyclosporine
Cyproterone
Dabrafenib
Deferasirox
Dehydroepiandosterone
Dexamethasone
Diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, nateglinide, rosiglitazone, saxagliptin)
Dipyridamole
Doxorubicin
Dronedarone
Efavirenz
Etravirine
Grapefruit juice
HIV protease inhibitors (e.g., lopinavir, ritonavir, saquinavir)
Lenalidomide
Mefloquine
Mitotane
Modafinil
Nefazodone
Pilotinib
Phenytoin
Primidone
Progesterone
Propranolol
Quinidine
Quinine
Rifabutin
Rifampin
Ropinirole
St. John’s wort
Somatropin
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Temazepam
Tenofovir
Teriflunomide
Thalidomide
Theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
Thyroid medications (e.g., levothyroxine, liothyronine)
Tizanidine
Tocilizumab
Trazodone
Ursodiol
Verapamil
Vinblastine
Warfarin

Ask your doctor and get the full list of drugs that may increase the possibility of drug interactions or interfere with the effectiveness of Progynova 1 mgTablet.

Estradiol Ingredients

Progynova 1 mg tablet comprises of an active pharmaceutical ingredient calledEstradiol. It belongs to the class of medication known as estrogen replacement therapy. Estradiol works by replacing the loss of estrogen which is a female sex hormone produced by ovaries. Loss of estrogen occurs when the women reaches to menopause, this condition leads to various unwanted symptoms such as hot flushes, abnormal uterine bleeding, sweating, and chills. This drug helps treat these symptoms, as this drug acts as a natural hormone known as estrogen. Estradiol also help in the prevention of osteoporosis in women when combined with diet, calcium, vitamin D, and exercise.

Storage information for Estradiol

Progynovatablets should be stored in a safe place that is away from heat and moisture. Do not refrigerate. Keep it out of the reach of children and pets. Do not keep the tablets out in open.

Estradiol Manufacturer

Progynovatabletis manufactured by Zydus Healthcare, India. It is an Indian multinational pharmaceutical company. It develops and manufactures the pharmaceutical products. You can easily buy Progynova 1 mg tablets online from our website and we will deliver this product at your doorsteps.