Taking Estradiol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Letrozole
Brand(s): Bestova L (LIFE-THREATENING)


Clomiphene/Clomifene
Brand(s): Fetrop (LIFE-THREATENING)


Danazol
Brand(s): Benzol (LIFE-THREATENING)

Concurrent use of Estradiol and Danazol should be avoided. There is a theoretical risk that the effects of both Estradiol and Danazol might be altered or reduced on concurrent use.


Phenobarbitone
Brand(s): Shinosun (MODERATE)


Teneligliptin
Brand(s): Tensorin, Zeptin (MODERATE)


Topiramate
Brand(s): Toprisun (MODERATE)


Phenytoin
Brand(s): Stoin (MODERATE)


Metformin
Brand(s): Exeed (MODERATE)


Acarbose
Brand(s): Diadose (MODERATE)


Glimepiride
Brand(s): Euroglip (MODERATE)

Dose adjustment of Glimepiride is required while taking Estradiol and it is recommended to monitor the blood glucose levels regularly.